The impact of aprotinin on renal function after liver transplantation: an analysis of 1,043 patients.

@article{Warnaar2007TheIO,
  title={The impact of aprotinin on renal function after liver transplantation: an analysis of 1,043 patients.},
  author={Nienke Warnaar and Susan V Mallett and Marieke T. de Boer and Nancy Rolando and Andrew K. Burroughs and Maarten W. N. Nijsten and Maarten J. H. Slooff and Keith Rolles and Robert J Porte},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2007},
  volume={7 10},
  pages={2378-87}
}
Renal dysfunction is frequently seen after orthotopic liver transplantation (OLT). Aprotinin is an antifibrinolytic drug which reduces blood loss during OLT. Recent studies in cardiac surgery suggested a higher risk of postoperative renal complications when aprotinin is used. The impact of aprotinin on renal function after OLT, however, is unknown. In 1,043 adults undergoing OLT, we compared postoperative renal function in patients who received aprotinin (n = 653) or not (n = 390). Using… CONTINUE READING