The impact of analytic method on interpretation of outcomes in longitudinal clinical trials

@article{Prakash2008TheIO,
  title={The impact of analytic method on interpretation of outcomes in longitudinal clinical trials},
  author={Apurva Prakash and Richard C Risser and Craig Mallinckrodt},
  journal={International Journal of Clinical Practice},
  year={2008},
  volume={62},
  pages={1147 - 1158}
}
AIMS Various analytical strategies for addressing missing data in clinical trials are utilised in reporting study results. The most commonly used analytical methods include the last observation carried forward (LOCF), observed case (OC) and the mixed model for repeated measures (MMRM). Each method requires certain assumptions regarding the characteristics of the missing data. If the assumptions for any particular method are not valid, results from that method can be biased. Results based on… CONTINUE READING

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