The impact of an end-point committee in a large multicentre, randomized, placebo-controlled clinical trial: results with and without the end-point committee's final decision on end-points.

@article{Nslund1999TheIO,
  title={The impact of an end-point committee in a large multicentre, randomized, placebo-controlled clinical trial: results with and without the end-point committee's final decision on end-points.},
  author={Ulf N{\"a}slund and Lars Grip and J\orgen Fischer-Hansen and Torstein Gundersen and Seppo Lehto and Lars Wallentin},
  journal={European heart journal},
  year={1999},
  volume={20 10},
  pages={771-7}
}
BACKGROUND A multicentre study permits rapid recruitment of a large number of patients. However, there is a risk of heterogeneities in end-point evaluations, as complex definitions of criteria are interpreted by several local investigators from different hospitals. Reports discussing end-point evaluation are sparse. The TRIM trial was a multicentre trial of a thrombin inhibitor in patients with unstable angina or non-Q myocardial infarction. In this study, an independent end-point committee… CONTINUE READING

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