The impact of alternative splicing in vivo: mouse models show the way.

@article{Moeroey2007TheIO,
  title={The impact of alternative splicing in vivo: mouse models show the way.},
  author={Tarik Moeroey and Florian Heyd},
  journal={RNA},
  year={2007},
  volume={13 8},
  pages={1155-71}
}
Alternative splicing is widely believed to have a major impact on almost all biological processes since it increases proteome complexity and thereby controls protein function. Recently, gene targeting in mice has been used to create in vivo models to study the regulation and consequences of alternative splicing. The evidence accumulated so far argues for a nonredundant, highly specific role of individual splicing factors in mammalian development, and furthermore, demonstrates the importance of… CONTINUE READING

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