The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.

@article{Dumble2007TheIO,
  title={The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.},
  author={Melissa L Dumble and Lynette M. Moore and Stuart M. Chambers and Hartmut Geiger and Gary E Van Zant and Margaret A. Goodell and Lawrence A. Donehower},
  journal={Blood},
  year={2007},
  volume={109 4},
  pages={1736-42}
}
A temporal decline in tissue stem cell functionality may be a key component of mammalian aging. The tumor suppressor p53 has recently been implicated as a potential regulator of aging. We examined age-associated hematopoietic stem cell (HSC) dynamics in mice with varying p53 activities. Reduced p53 activity in p53+/- mice was associated with higher numbers of proliferating hematopoietic stem and progenitor cells in old age compared with aged wild-type (p53+/+) mice. We also assessed HSC… CONTINUE READING