The impact of aging on kidney repair.
@article{Schmitt2008TheIO,
title={The impact of aging on kidney repair.},
author={Roland Schmitt and Lloyd G. Cantley},
journal={American journal of physiology. Renal physiology},
year={2008},
volume={294 6},
pages={
F1265-72
}
}The process of normal aging affects organ homeostasis as well as responses to acute and chronic injury. In view of the rapid growth in the elderly population, it is increasingly important for us to develop a mechanistic understanding of how these age-dependent changes can impact the susceptibility and response of the kidney to injurious stimuli. In this overview, we focus on the current understanding of those mechanisms by reviewing how cellular changes in the aging kidney might lead to a…
143 Citations
Chapter 27 – The Molecular Response to Renal Injury: How Does Chronic Renal Damage Suppress Normal Repair Processes?
- Biology, Medicine
- 2016
Aging and the kidney
- BiologyCurrent opinion in nephrology and hypertension
- 2011
Recent advances in understanding the role of Klotho, sirtuins, cell senescence through oxidative stress and mitochondrial dysfunction, as well as of the renin–angiotensin system in modulating age-related kidney damage are reviewed.
Pathophysiology of the aging kidney and therapeutic interventions
- Medicine, BiologyHypertension Research
- 2012
The physiology and pathogenesis of kidney aging is discussed and potential therapeutic strategies for halting the aging process in the kidneys are analyzed.
Cell senescence in the aging kidney.
- Medicine, BiologyJournal of the American Society of Nephrology : JASN
- 2010
New progress in understanding renal aging is discussed, focusing on mechanisms of cell senescence and possible interventions to modulate age-related organ damage.
Effects of Aging on Renal Function and Regenerative Capacity
- MedicineNephron Clinical Practice
- 2014
Biological processes of aging that predispose patients to AKI and CKD are discussed, and comorbidities associated with aging are discussed.
Aging, Cellular Senescence, and Kidney Fibrosis
- Medicine, BiologyCurrent Pathobiology Reports
- 2017
Drawing from data from various disciplines, senescence-associated secretory phenotype, klotho, and senotherapy is discussed, analyzing the research and looking for new solutions to age-related kidney fibrosis.
The Aging Kidney: Increased Susceptibility to Nephrotoxicity
- Medicine, BiologyInternational journal of molecular sciences
- 2014
Mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair are focused on.
Is cellular senescence important in pediatric kidney disease?
- Medicine, BiologyPediatric Nephrology
- 2011
As SCS seems to accelerate CKD and cardiovascular disease progression, developing strategies for new treatment options that overcome SCS or protect a patient from it represents an exciting challenge.
References
SHOWING 1-10 OF 131 REFERENCES
Functional Decline in Aging and Disease: A Role for Apoptosis
- MedicineJournal of the American Geriatrics Society
- 2001
There is evidence that advanced age is associated with dysregulation of apoptosis, which could explain the age‐associated increased prevalence of cancers, certain autoimmune diseases, and neurodegenerative disorders in older people.
Molecular events in kidney ageing
- Medicine, BiologyCurrent opinion in nephrology and hypertension
- 2005
Despite significant progress, cellular senescence is still better understood in vitro than in vivo, and so far, p16INK4a remains the best marker of chronological age in the kidney, and can be considered as an indicator of prematuresenescence caused by stresses or disease.
Adult stem cells in the repair of the injured renal tubule
- Medicine, BiologyNature Clinical Practice Nephrology
- 2005
The current understanding of adult stem cells, the controversies surrounding their in vivo capacity to repopulate the renal tubule, and further investigations that will be required before stem cell therapy can be considered for use in the clinical setting are focused on.
Cell cycle regulation: repair and regeneration in acute renal failure.
- Biology, MedicineSeminars in nephrology
- 2003
Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 2007
These experiments were designed to investigate the influence of age on the response of the kidney to ischemic injury and to identify candidate genes that may mediate this response, and identified genes changed by aging and changes attenuated by caloric restriction.
Effects of aging on expression of ischemic acute renal failure in rats.
- Medicine, BiologyLaboratory investigation; a journal of technical methods and pathology
- 1989
It is concluded that aging increases susceptibility to severe ischemic acute renal failure in the rat, an effect that is apparent even during a transition from the adolescent to the mature state.
Ischemic acute renal failure: an inflammatory disease?
- Biology, MedicineKidney international
- 2004
The ability of the mouse kidney to be protected by prior exposure to ischemia or urinary tract obstruction is discussed as a potential model to emulate as the search for pharmacologic agents that will serve to protect the kidney against injury continues.
Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis.
- BiologyAmerican journal of physiology. Renal physiology
- 2003
Evaluation of the understanding of the molecular signaling events in apoptotic and necrotic cell death and the contribution of various molecular components of these pathways to renal injury and the design of potential therapeutic strategies is evaluated.
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
- BiologyAnnals of the New York Academy of Sciences
- 2000
The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
Stem cells, ageing and the quest for immortality
- Biology, MedicineNature
- 2006
Unravelling distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.