The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance

@article{Vajapey2014TheIO,
  title={The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance},
  author={Ramya Vajapey and D. Rini and J. Walston and P. Abadir},
  journal={Frontiers in Physiology},
  year={2014},
  volume={5}
}
Aging is associated with the accumulation of various deleterious changes in cells. According to the free radical and mitochondrial theory of aging, mitochondria initiate most of the deleterious changes in aging and govern life span. The failure of mitochondrial reduction-oxidation (redox) homeostasis and the formation of excessive free radicals are tightly linked to dysregulation in the Renin Angiotensin System (RAS). A main rate-controlling step in RAS is renin, an enzyme that hydrolyzes… Expand
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