The impact of age and frailty on ventricular structure and function in C57BL/6J mice

  title={The impact of age and frailty on ventricular structure and function in C57BL/6J mice},
  author={H. A. Feridooni and A. Kane and O. Ayaz and A. Boroumandi and N. Polidovitch and R. Tsushima and R. Rose and S. Howlett},
  journal={The Journal of Physiology},
  • H. A. Feridooni, A. Kane, +5 authors S. Howlett
  • Published 2017
  • Medicine, Chemistry
  • The Journal of Physiology
  • Heart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a ‘frailty index’. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac hypertrophy… CONTINUE READING
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