The impact of age and frailty on ventricular structure and function in C57BL/6J mice.

@article{Feridooni2017TheIO,
  title={The impact of age and frailty on ventricular structure and function in C57BL/6J mice.},
  author={Hirad A. Feridooni and Alice Elizabeth Kane and Omar Ayaz and Ali Boroumandi and Nazari Polidovitch and Robert G. Tsushima and Robert A. Rose and Susan E Howlett},
  journal={The Journal of physiology},
  year={2017},
  volume={595 12},
  pages={
          3721-3742
        }
}
KEY POINTS Heart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a 'frailty index'. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac… CONTINUE READING
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