The impact of age and frailty on ventricular structure and function in C57BL/6J mice

@article{Feridooni2017TheIO,
  title={The impact of age and frailty on ventricular structure and function in C57BL/6J mice},
  author={H. A. Feridooni and A. Kane and O. Ayaz and A. Boroumandi and N. Polidovitch and R. Tsushima and R. Rose and S. Howlett},
  journal={The Journal of Physiology},
  year={2017},
  volume={595}
}
  • H. A. Feridooni, A. Kane, +5 authors S. Howlett
  • Published 2017
  • Medicine, Chemistry
  • The Journal of Physiology
  • Heart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a ‘frailty index’. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac hypertrophy… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    The impacts of age and frailty on heart rate and sinoatrial node function
    • 42
    • PDF
    A procedure for creating a frailty index based on deficit accumulation in aging mice.
    • 132
    • PDF
    Sex Differences in the Biology and Pathology of the Aging Heart.
    • 60
    • PDF
    Implementation of the mouse frailty index.
    • 13
    • PDF
    Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.
    • 81
    • PDF
    Frailty assessment in the cardiovascular care of older adults.
    • 549
    • PDF
    A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans
    • 173
    • PDF
    Frailty in Advanced Heart Failure: A Consequence of Aging or a Separate Entity?
    • 26
    • PDF
    Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease
    • 143
    • Highly Influential
    A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
    • 120
    • PDF