The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum


Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer's disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight… (More)
DOI: 10.1038/srep24480


6 Figures and Tables