The impact of H2-DM on humoral immune responses.

@article{Alfonso2001TheIO,
  title={The impact of H2-DM on humoral immune responses.},
  author={Christopher Alfonso and Jiahuai Han and Gareth Stewart Williams and Liselott Karlsson},
  journal={Journal of immunology},
  year={2001},
  volume={167 11},
  pages={
          6348-55
        }
}
H2-DM (DM, previously H2-M) facilitates the exchange of peptides bound to MHC class II molecules. In this study, we have used H2-DM-deficient (DM(-/-)) mice to analyze the influence of DM in the priming of B cell responses in vivo and for Ag presentation by B cells in vitro. After immunization, IgG Abs could be raised to a T-dependent Ag, 4-hydroxy-5-nitrophenylacetyl-OVA, in DM(-/-) mice, but closer analysis revealed the IgG response to be slower, diminished in titer, and composed of low… CONTINUE READING
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