The impact of CMV infection on survival in older humans.

  title={The impact of CMV infection on survival in older humans.},
  author={Graham P Pawelec and Janet E. McElhaney and Allison E Aiello and Evelyna Derhovanessian},
  journal={Current opinion in immunology},
  volume={24 4},
Dysregulated immunity, 'immunosenescence', in the elderly is thought to contribute to their increased susceptibility to infectious disease and to impact on mortality. Accepted hallmarks of human immunosenescence are low numbers and frequencies of naïve T cells and higher numbers and frequencies of memory T cells in the peripheral blood of the elderly compared to the young. The proportion of the population infected with CMV increases with age and markedly influences these parameters. Infection… CONTINUE READING

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Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

  • NH Litjens, EA de Wit, MG Betjes
  • Immun Aging
  • 2011
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