The impact of Alzheimer's disease on the functional connectivity between brain regions underlying pain perception.

@article{Cole2011TheIO,
  title={The impact of Alzheimer's disease on the functional connectivity between brain regions underlying pain perception.},
  author={Leonie J. Cole and Maria Gavrilescu and Leigh A. Johnston and Stephen J. Gibson and Michael J. Farrell and Gary F. Egan},
  journal={European journal of pain},
  year={2011},
  volume={15 6},
  pages={568.e1-11}
}
Patients with Alzheimer's disease (AD) are administered fewer analgesics and report less clinical pain compared with their cognitively-intact peers, prompting much speculation about the likely impact of neurodegeneration on pain perception and processing. This study used functional connectivity analysis to examine the impact of AD on the integrated functioning of brain regions mediating the sensory, emotional, and cognitive aspects of pain. Fourteen patients with AD and 15 controls attended two… CONTINUE READING

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