The impact of 6-thioguanine incorporation into DNA on the function of DNA methyltransferase Dnmt3a.

Abstract

The incorporation of chemotherapeutic agent 6-thioguanine (SG) into DNA is a prerequisite for its cytotoxic action. This modification of DNA impedes the activity of enzymes involved in DNA repair and replication. Here, using hemimethylated DNA substrates we demonstrated that DNA methylation by Dnmt3a-CD is reduced if DNA is damaged by the incorporation of… (More)
DOI: 10.1080/15257770.2017.1287921

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