The immunotherapeutic potential of melatonin

@article{Maestroni2001TheIP,
  title={The immunotherapeutic potential of melatonin},
  author={Georges J. M. Maestroni},
  journal={Expert Opinion on Investigational Drugs},
  year={2001},
  volume={10},
  pages={467 - 476}
}
  • G. Maestroni
  • Published 1 March 2001
  • Biology
  • Expert Opinion on Investigational Drugs
The interaction between the brain and the immune system is essential for the adaptive response of an organism against environmental challenges. In this context, the pineal neurohormone melatonin (MEL) plays an important role. T-helper cells express G-protein coupled cell membrane MEL receptors and, perhaps, MEL nuclear receptors. Activation of MEL receptors enhances the release of T-helper cell Type 1 (Th1) cytokines, such as γ-interferon (γ-IFN) and IL-2, as well as of novel opioid cytokines… 
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