The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.

@article{Chhabra2012TheIR,
  title={The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.},
  author={Preeti Chhabra and Joel Lind{\'e}n and Peter I. Lobo and Mark Douglas Okusa and Kenneth L. Brayman},
  journal={Current diabetes reviews},
  year={2012},
  volume={8 6},
  pages={
          419-33
        }
}
Activation of adenosine A2A receptors (A2AR) reduces inflammation by generally inhibiting the activation of pro-inflammatory cells, decreasing endothelial adhesion molecule expression and reducing the release of proinflammatory cytokine mediators. Numerous preclinical studies using selective A2AR agonists, antagonists, A2AR knockout as well as chimeric mice have suggested the therapeutic potential of A2AR agonists for the treatment of ischemia reperfusion injury (IRI) and autoimmune diseases… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Dipyridamole attenuates ischemia reperfusion induced acute kidney injury through adenosinergic A1 and A2A receptor agonism in rats

  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED