The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells

@inproceedings{ShimabukuroVornhagen2012TheIF,
  title={The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells},
  author={Alexander Shimabukuro-Vornhagen and Andreas Draube and Tanja M. Liebig and Achim Rothe and Matthias Kochanek and Michael S. von Bergwelt-Baildon},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2012}
}
BACKGROUND Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factors such as IL-10, TGF-β, and VEGF suppress effector cells either directly or indirectly by disruption of dendritic cell (DC) differentiation, migration and antigen presentation. Human B cells acquire potent immunostimulatory properties when activated via CD40 and have been shown… CONTINUE READING
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