The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function.

@article{Ramasamy2008TheIE,
  title={The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function.},
  author={Rajesh Ramasamy and Chih Kong Tong and Heng Fong Seow and Sharmili Vidyadaran and Francesco Dazzi},
  journal={Cellular immunology},
  year={2008},
  volume={251 2},
  pages={131-6}
}
Mesenchymal stem cells (MSC) are non-haematopoietic stem cells that are capable of differentiating into tissues of mesodermal origin. MSC play an important role in supporting the development of fetal and adult haematopoiesis. More recently, MSC have also been found to exhibit inhibitory effect on T cell responses. However, there is little information on the mechanism of this immunosuppression and our study addresses this issue by targeting T cell functions at various level of immune responses… CONTINUE READING
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