The immunoregulatory roles of natural killer T cells in cyclophosphamide-induced tolerance.

@article{Iwai2007TheIR,
  title={The immunoregulatory roles of natural killer T cells in cyclophosphamide-induced tolerance.},
  author={Toshiro Iwai and Yukihiro Tomita and Ichiro Shimizu and Takashi Kajiwara and Tatsushi Onzuka and Shinji Okano and Yohichi Yasunami and Yasunobu Yoshikai and Kikuo Nomoto and Ryuji Tominaga},
  journal={Transplantation},
  year={2007},
  volume={84 12},
  pages={1686-95}
}
BACKGROUND Recent studies have indicated that natural killer T (NKT) cells are essential for the establishment of transplantation tolerance. In the present study, we have elucidated the role of recipient and donor NKT cells in cyclophosphamide (CP)-induced tolerance. METHOD DBA/2 (DBA; H-2) mice were used as donors and BALB/c (BALB; H-2) wild-type (WT) or Valpha14 NKT-knockout (KO, BALB/c background) mice were used as recipients. Recipients were treated with CP-induced tolerance regimen… CONTINUE READING