The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS

@article{GiovannaQuaranta2006TheIE,
  title={The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS},
  author={Maria Giovanna Quaranta and Benedetta Mattioli and Luciana Giordani and Marina Viora},
  journal={The FASEB Journal},
  year={2006},
  volume={20}
}
Dendritic cells (DC) play a crucial role in the generation and regulation of immunity, and their interaction with HIV is relevant in the pathogenesis of AIDS favoring both the initial establishment and spread of the infection and the development of antiviral immunity. HIV‐1 Nef is an essential factor for efficient viral replication and pathogenesis, and several studies have been addressed to assess the possible influence of endogenous or exogenous Nef on DC biology. Our findings and other… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this research study is to 1) evaluate the safety of a series of injections with the AGS-004 product in combination with a series of Vorinostat doses and 2) to help… Expand
ConditionsHIV-1 Infection
InterventionBiological, Drug
Interventional Clinical Trial
The purpose of this study is to: - find out the intensity and duration of the immune response after multiple injections of the investigational study product AGS-004… Expand
ConditionsHIV
InterventionBiological
Immunoregulatory effects of HIV‐1 Nef protein
TLDR
Recent progress on the immunomodulatory effect of the accessory Nef protein and its role in the pathogenesis of HIV‐1 infection are reviewed. Expand
Plasmacytoid dendritic cells in HIV infection: striking a delicate balance
TLDR
The status of pDC in individuals with HIV‐1 infection and the potential role of these cells in pathogenesis are reviewed and the evidence that chronic production of IFN‐α, probably through the chronic activated pDC, is central to the immune activation that is so detrimental in HIV infection is reviewed. Expand
HIV‐1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56dim and CD56bright NK cell subsets
TLDR
It is demonstrated that Nef up‐regulates the ability of DCs to stimulate the immunoregulatory NK cells (CD56bright) as assessed by the activated phenotype, up‐regulation of their proliferative response and INF‐γ release, and it is suggested that the Nef‐induced dysregulation in the DC/NK crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance. Expand
Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction
TLDR
Findings are focused on which collectively add new insights on how Nef-induced CCL2 expression contributes to neurotropism and neurovirulence of HIV and SIV and elucidates why adjuvant targeting of CCL 2 could be a therapeutic option for HIV-infected persons. Expand
Intracellular Overexpression of HIV-1 Nef Impairs Differentiation and Maturation of Monocytic Precursors towards Dendritic Cells
TLDR
It is demonstrated that long-lasting expression of Nef at high levels indeed retards differentiation and maturation of dendritic cells in terms of phenotype and morphology, and it is hopeful that potentially, stable expression of intracellular Nef in vivo may function as a subtle mode to support long- lasting HIV-1 existence. Expand
Plasmacytoid dendritic cells in HIV infection.
TLDR
This chapter discusses pDC biology, including pDC development from progenitors, trafficking and localization of pDCs in the body, and signaling pathways involved in pDC activation, and immunosuppression through regulatory T cell development. Expand
HIV-1 Induction of Tolerogenic DCs is Mediated by Cellular Interaction with Suppressive T Cells
TLDR
The data indicate that the prolonged and strong IFN type I signaling induced by the presence of HIV during DC-T cell cross talk could play an important role in the induction of the tolerogenic DCs and suppressed immune response. Expand
HIV-1 Nef Signaling in Intestinal Mucosa Epithelium Suggests the Existence of an Active Inter-kingdom Crosstalk Mediated by Exosomes
TLDR
The effects of HIV-1 Nef protein on intestinal epithelium are discussed, the existence of an inter-kingdom communication process mediated by exosomes is proposed and the potential inter-Kingdom communication pathway between virus and humans is considered. Expand
Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection
PurposeThis review summarizes recent literature on the biology of dendritic cells and natural killer cells in HIV-1 infection and the importance of crosstalk between them in the development of strongExpand
Extracellular HIV-1 Nef protein modulates lytic activity and proliferation of human CD8+ T lymphocytes.
TLDR
Concentrations of exNef commonly found in sera of HIV-infected patients were found to modulate the induction of lytic activity and proliferation of CD8+ T lymphocytes in vitro, to an extent strongly dependent on the quite variable responsiveness of each donor. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 136 REFERENCES
Biology of the HIV Nef protein.
  • S. Das, S. Jameel
  • Biology, Medicine
  • The Indian journal of medical research
  • 2005
TLDR
These biological properties of Nef are presented from a mechanistic point of view, and relate them to the structural attributes and interactions of the Nef protein. Expand
HIV‐1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion
TLDR
It is found that Nef inhibits the capacity of DCs to prime alloreactive CD8+ T cell responses down‐regulating their proliferation and functional competence, which may help explain the pleiotropic function thatNef plays during infection and makes this protein an attractive target for preventive and therapeutic intervention. Expand
The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector.
TLDR
In this study, HIV-1 (SF2 strain) Nef was expressed in human monocyte-derived dendritic cells, using an adenovirus based delivery system and stimulated a strong recall CD4 response in all individuals tested. Expand
HIV‐1 Nef mediates post‐translational down‐regulation and redistribution of the mannose receptor
TLDR
The MR is reduced on the cell surface by ∼50% in the presence of Nef and the MR cytoplasmic tail can confer susceptibility to Nef in the CD4/MR chimera, suggesting that the MR is a potential intracellular target ofNef and that this regulation may represent a mechanism to further crippled the host innate immune system. Expand
HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis.
TLDR
The Nef anti-apoptotic effect is proposed as a relevant part of the mechanism of the in vivo establishment of the HIV macrophage reservoirs. Expand
HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization.
TLDR
A hybrid CD8-Nef protein is expressed in Jurkat cells and its positional effects reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, which explains effects of Nf in HIV infection and progression to AIDS. Expand
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
TLDR
It is shown that HIV-1 Nef associates with and inhibits apoptosis signal-regulating kinase 1 (ASK1), a serine/threonine kinase that forms a common and key signalling intermediate in the Fas and tumour-necrosis factor-α (TNFα) death-signalling pathways. Expand
HIV-1 Nef induces dendritic cell differentiation: a possible mechanism of uninfected CD4(+) T cell activation.
TLDR
Results indicate that rNef induces a coordinate series of phenotypic and functional changes promoting DC differentiation and making them more competent APCs, thus promoting virus dissemination. Expand
HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors.
TLDR
The results indicate that HIV-1 Nef could interfere with STAT1-governed intracellular signaling in human monocytes/macrophages. Expand
Induction of interleukin-15 production by HIV-1 nef protein: a role in the proliferation of uninfected cells.
TLDR
It is found that exogenous Nef protein induces activation of normal PBMC, increasing their proliferative response; modulates cytokine production; exerts its activating effects through IL-15 synthesis induction; and exerts these effects entering monocyte/macrophages. Expand
...
1
2
3
4
5
...