The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS

  title={The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS},
  author={Maria Giovanna Quaranta and B. Mattioli and L. Giordani and M. Viora},
  journal={The FASEB Journal},
  • Maria Giovanna Quaranta, B. Mattioli, +1 author M. Viora
  • Published 2006
  • Biology, Medicine
  • The FASEB Journal
  • Dendritic cells (DC) play a crucial role in the generation and regulation of immunity, and their interaction with HIV is relevant in the pathogenesis of AIDS favoring both the initial establishment and spread of the infection and the development of antiviral immunity. HIV‐1 Nef is an essential factor for efficient viral replication and pathogenesis, and several studies have been addressed to assess the possible influence of endogenous or exogenous Nef on DC biology. Our findings and other… CONTINUE READING
    33 Citations

    Paper Mentions

    Interventional Clinical Trial
    The purpose of this research study is to 1) evaluate the safety of a series of injections with the AGS-004 product in combination with a series of Vorinostat doses and 2) to help… Expand
    ConditionsHIV-1 Infection
    InterventionBiological, Drug
    Interventional Clinical Trial
    The purpose of this study is to: - find out the intensity and duration of the immune response after multiple injections of the investigational study product AGS-004 made… Expand
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    Biology of the HIV Nef protein.
    • S. Das, S. Jameel
    • Biology, Medicine
    • The Indian journal of medical research
    • 2005
    • 118
    • PDF
    HIV‐1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion
    • 44
    HIV‐1 Nef mediates post‐translational down‐regulation and redistribution of the mannose receptor
    • 36
    HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis.
    • 61
    HIV-1 Nef induces dendritic cell differentiation: a possible mechanism of uninfected CD4(+) T cell activation.
    • 74