The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

@inproceedings{Crotti2012TheIT,
  title={The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints},
  author={Tania Narelle Crotti and Anak Assk Dharmapatni and Ekram Alias and Andrew C. W. Zannettino and MaryD. Smith and David Haynes},
  booktitle={Arthritis research & therapy},
  year={2012}
}
INTRODUCTION The immunoreceptor tyrosine-based activation motif (ITAM) pathway provides osteoclast co-stimulatory signals and regulates proliferation, survival and differentiation of effector immune cells. In the osteoclast, the receptors Triggering Receptor Expressed on Myeloid cells 2 (TREM2) and Osteoclast Associated Receptor (OSCAR) and their respective adaptor proteins, DAP12 and FcRγ mediate ITAM signals and induce calcium signaling and the crucial transcription factor, NFATc1. In… CONTINUE READING
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