The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.

  title={The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.},
  author={Robert J. Johnston and Laetitia Comps-Agrar and Jason A Hackney and X. Christopher Yu and Mahrukh A. Huseni and Yagai Yang and Summer Park and Vincent Javinal and Henry Chiu and Bryan A. Irving and Dan L. Eaton and Jane L. Grogan},
  journal={Cancer cell},
  volume={26 6},
Tumors constitute highly suppressive microenvironments in which infiltrating T cells are "exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory receptor that critically limits antitumor and other CD8(+) T cell-dependent chronic immune responses. TIGIT is highly expressed on human and murine tumor-infiltrating T cells, and, in models of both cancer and chronic viral infection, antibody coblockade of TIGIT and PD-L1 synergistically and specifically enhanced CD8… CONTINUE READING
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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 T Cell Effector Function

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  • M. Cella, R. Presti, +7 authors I Williams
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