The immunophenotype of osteoclasts and macrophage polykaryons.

  title={The immunophenotype of osteoclasts and macrophage polykaryons.},
  author={F Maggiani and Ramses Forsyth and P. C. W. Hogendoorn and Tibor Kr{\`e}nacs and Nicholas A Athanasou},
  journal={Journal of clinical pathology},
  volume={64 8},
AIM Osteoclasts are multinucleated cells which are specialised to carry out lacunar bone resorption. Osteoclasts form part of the mononuclear phagocyte system, and immunophenotypic criteria for distinction from macrophage polykaryons include expression of CD51 (vitronectin receptor) and absence of HLA-DR and CD14. METHODS The expression of CD14, CD163, HLA-DR and CD51 in formalin-fixed paraffin-embedded sections of normal bone and neoplastic and non-neoplastic lesions of bone and soft tissue… CONTINUE READING


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