The immunopathogenic role of complement in human muscle disease

  title={The immunopathogenic role of complement in human muscle disease},
  author={J. Mendell and T. Garcha and J. Kissel},
  journal={Current Opinion in Neurology},
The complement system has been shown to play a pathogenic role in only a small number of muscle diseases. A complement-induced microangiopathy is important in dermatomyositis and in the rare disorder, necrotizing myopathy with pipestem capillaries. Recent studies demonstrate the reversibility of micovascular damage in dermatomyositis by intravenous immune globulin which appears to intercept the assembly and deposition of membrane attack complex. In myasthenia gravis, complement-mediated lysis… Expand
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