The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases.

@article{Miller1994TheIA,
  title={The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases.},
  author={Stephen D Miller and William J. Karpus},
  journal={Immunology today},
  year={1994},
  volume={15 8},
  pages={356-61}
}
A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases. 

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