The immunomodulatory role of CD4-positive cytotoxic T-lymphocytes in health and disease.

@article{Hahn1999TheIR,
  title={The immunomodulatory role of CD4-positive cytotoxic T-lymphocytes in health and disease.},
  author={Sinuhe Hahn and Peter Erb},
  journal={International reviews of immunology},
  year={1999},
  volume={18 5-6},
  pages={449-64}
}
Among the CD4-positive (CD4+) T-lymphocytes a population exists which expresses cytolytic activity. These 'killer' cells belong to the T helper type 1 (Th1) subset and if activated, express Fas-ligand (FasL) which induces apoptosis in Fas-positive target cells. The major targets of these CD4+ cytotoxic T-lymphocytes (CTL) are cells of the immune system, such as T, B cells and macrophages which express Fas upon activation. Thus, CD4+ CTL play a major immunoregulatory part through the elimination… CONTINUE READING