The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy.

@article{Stratton2016TheIP,
  title={The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy.},
  author={Jo Anne Stratton and Prajay T Shah and Ranjan Kumar and Morgan Stykel and Yuval Shapira and Joey K Grochmal and Gui Fang Guo and Jeff Biernaskie and Rajiv Midha},
  journal={The European journal of neuroscience},
  year={2016},
  volume={43 3},
  pages={365-75}
}
Skin-derived precursor Schwann cell (SKPSC) therapy has been identified as a potentially beneficial treatment for peripheral nerve injuries. One hypothesised mechanism by which SKPSCs enhance recovery is via the modulation of macrophages. In the present study, we investigated the immunomodulatory properties of adult rat SKPSCs, and demonstrated that these cells expressed a battery of cytokines, including interferon-γ (IFN-γ), interleukin (IL)-1β, and, most abundantly, IL-6. Whereas macrophages… CONTINUE READING

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