The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission.

@article{Titus2006TheIF,
  title={The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission.},
  author={Richard G. Titus and Jeanette V. Bishop and J. Santiago Mejia},
  journal={Parasite immunology},
  year={2006},
  volume={28 4},
  pages={131-41}
}
In general, attempts to develop vaccines for pathogens transmitted by arthropods have met with little or no success. It has been widely observed that the saliva of arthropods that transmit disease enhances the infectivity of pathogens the arthropod transmits to the vertebrate host. Indeed, it has been observed that vaccinating against components of the saliva of arthropods or against antigens expressed in the gut of arthropods can protect the host from infection and decrease the viability of… CONTINUE READING

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