The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients.

@article{Helmy2001TheIE,
  title={The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients.},
  author={Seham A. Helmy and Rajaa J. Al-Attiyah},
  journal={Anaesthesia},
  year={2001},
  volume={56 1},
  pages={4-8}
}
Both propofol and midazolam are known to inhibit immune function. The aim of this study was to investigate cytokine production in critically ill surgical patients as early markers of immune response to prolonged infusion of propofol and midazolam. The study enrolled 40 elective patients who were to receive long-term sedation for more than 2 days. Patients were randomly allocated to one of two equally sized groups. Central venous blood samples for measurement of interleukin-1beta (IL-1beta… CONTINUE READING

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