The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.

@article{Coelho2007TheIF,
  title={The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.},
  author={Rochelle P Coelho and Shawn G. Payne and Robert Bittman and Sarah Spiegel and Carmen Sato-Bigbee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={323 2},
  pages={626-35}
}
The immunomodulator 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (FTY720) has promising therapeutic effects in multiple sclerosis (MS), a degenerative disease in which demyelination of the central nervous system is accompanied by death of oligodendrocytes (OLGs), the myelin-producing cells. In vivo phosphorylation of FTY720 generates an agonist for G protein-coupled receptors for sphingosine-1-phosphate, a lipid mediator that plays a crucial role in the stimulation of OLG survival by… CONTINUE READING