The immunology of the allergy epidemic and the hygiene hypothesis

  title={The immunology of the allergy epidemic and the hygiene hypothesis},
  author={Bart M. Lambrecht and Hamida Hammad},
  journal={Nature Immunology},
The immunology of the hygiene hypothesis of allergy is complex and involves the loss of cellular and humoral immunoregulatory pathways as a result of the adoption of a Western lifestyle and the disappearance of chronic infectious diseases. The influence of diet and reduced microbiome diversity now forms the foundation of scientific thinking on how the allergy epidemic occurred, although clear mechanistic insights into the process in humans are still lacking. Here we propose that barrier… CONTINUE READING
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