The immunology of smallpox vaccines.

  title={The immunology of smallpox vaccines.},
  author={Richard B. Kennedy and Inna G. Ovsyannikova and Robert M. Jacobson and Gregory A. Poland},
  journal={Current opinion in immunology},
  volume={21 3},
In spite of the eradication of smallpox over 30 years ago; orthopox viruses such as smallpox and monkeypox remain serious public health threats both through the possibility of bioterrorism and the intentional release of smallpox and through natural outbreaks of emerging infectious diseases such as monkeypox. The eradication effort was largely made possible by the availability of an effective vaccine based on the immunologically cross-protective vaccinia virus. Although the concept of… CONTINUE READING