The immunology of leprosy: speculations on the leprosy spectrum.

  title={The immunology of leprosy: speculations on the leprosy spectrum.},
  author={Philippe J Sansonetti and Philippe Henri Lagrange},
  journal={Reviews of infectious diseases},
  volume={3 3},
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The disease presents a wide spectrum of clinical manifestations, ranging from lepromatous to tuberculoid leprosy; each form may be punctuated by episodes of acute exacerbation, called reactional states. These polar forms and reactional states appear to be determined by immunologic interactions between the host and the microorganism. This review describes the different measurable parameters that permit the classification of… CONTINUE READING

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