The immunological synapse balances T cell receptor signaling and degradation.

@article{Lee2003TheIS,
  title={The immunological synapse balances T cell receptor signaling and degradation.},
  author={Kyeong-Hee Lee and Aaron R. Dinner and Chun Tu and Gabriele Campi and Subhadip Raychaudhuri and Rajiv R. Varma and Tasha Nicholle Sims and W Richard Burack and Hui Wu and Julia Wang and Osami Kanagawa and Mary A Markiewicz and Paul McD. Allen and Michael L. Dustin and Arup K. Chakraborty and Andrey S Shaw},
  journal={Science},
  year={2003},
  volume={302 5648},
  pages={
          1218-22
        }
}
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T… CONTINUE READING

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