The immunological synapse: integrins take the stage.

@article{Sims2002TheIS,
  title={The immunological synapse: integrins take the stage.},
  author={Tasha Nicholle Sims and Michael L. Dustin},
  journal={Immunological reviews},
  year={2002},
  volume={186},
  pages={
          100-17
        }
}
Adhesive interactions play important roles in coordinating T-cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell-cell junction. Recent demonstrations show several molecules implicated in T-cell signaling, including Vav, ADAP, and Rap-1, have major roles in integrin regulation and place adhesion molecules at center stage in addressing the question: what are the signals involved in the formation of the IS and full T-cell activation… CONTINUE READING
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