The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

@article{Dhuban2015TheIA,
  title={The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.},
  author={Khalid Bin Dhuban and Ciriaco A Piccirillo},
  journal={Current opinion in allergy and clinical immunology},
  year={2015},
  volume={15 6},
  pages={525-32}
}
PURPOSE OF REVIEW This article presents a comprehensive review of the immunodysregulation, polyendocrinopathy, enteropathy and X-linked (IPEX) syndrome, covering both the clinical and molecular aspects of the disease. (Figure is included in full-text article.) RECENT FINDINGS The IPEX syndrome is a rare immunological disorder in humans caused by inheritable mutations in the FOXP3 gene, the master transcriptional regulator for the development and function of CD4 regulatory T (Treg) cells… CONTINUE READING
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