The immunohistologic features of synovitis, disease activity and in vitro IgM rheumatoid factor synthesis by blood mononuclear cells in rheumatoid arthritis.

@article{Rooney1989TheIF,
  title={The immunohistologic features of synovitis, disease activity and in vitro IgM rheumatoid factor synthesis by blood mononuclear cells in rheumatoid arthritis.},
  author={Madeleine M Rooney and Alex Whelan and Conleth Feighery and Barry Bresnihan},
  journal={The Journal of rheumatology},
  year={1989},
  volume={16 4},
  pages={459-67}
}
The immunohistologic characteristics of synovial membrane obtained from patients with active rheumatoid arthritis (RA) were correlated with disease activity and spontaneous in vitro synthesis of IgM rheumatoid factor (RF) by peripheral blood mononuclear cells (MNC). Positive correlations were found between the intensity of inflammatory cell infiltration and both disease activity (p = 0.0007) and RF synthesis (p = 0.028). Moreover, the intensity of both T cell and B cell infiltration correlated… CONTINUE READING