The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

@article{Inoue2005TheIS,
  title={The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs},
  author={Naokazu Inoue and Masahito Ikawa and Ayako Isotani and Masaru Okabe},
  journal={Nature},
  year={2005},
  volume={434},
  pages={234-238}
}
Representing the 60 trillion cells that build a human body, a sperm and an egg meet, recognize each other, and fuse to form a new generation of life. The factors involved in this important membrane fusion event, fertilization, have been sought for a long time. Recently, CD9 on the egg membrane was found to be essential for fusion, but sperm-related fusion factors remain unknown. Here, by using a fusion-inhibiting monoclonal antibody and gene cloning, we identify a mouse sperm fusion-related… CONTINUE READING
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