The immunoglobulin-like cell adhesion molecule hepaCAM induces differentiation of human glioblastoma U373-MG cells.

@article{Lee2009TheIC,
  title={The immunoglobulin-like cell adhesion molecule hepaCAM induces differentiation of human glioblastoma U373-MG cells.},
  author={Lay Hoon Lee and Mei Chung Moh and Taouri Zhang and Shali Shen},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 6},
  pages={
          1129-38
        }
}
Subsequent to our identification of a novel immunoglobulin-like cell adhesion molecule hepaCAM, we showed that hepaCAM is frequently lost in diverse human cancers and is capable of modulating cell motility and growth when re-expressed. Very recently, a molecule identical to hepaCAM (designated as GlialCAM) was found highly expressed in glial cells of the brain. Here, we demonstrate that hepaCAM is capable of inducing differentiation of the human glioblastoma U373-MG cells. Expression of hepaCAM… CONTINUE READING
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