The immunoglobulin constant region contributes to affinity and specificity.

@article{Torres2008TheIC,
  title={The immunoglobulin constant region contributes to affinity and specificity.},
  author={Marcela M Torres and Arturo Casadevall},
  journal={Trends in immunology},
  year={2008},
  volume={29 2},
  pages={91-7}
}
A central dogma in immunology is that antibody specificity is solely the result of variable (V)-region interactions with an antigen. However, this view is not tenable in light of numerous reports that constant heavy (C(H)) domains can affect binding affinity and specificity and V-region structure. Kinetic and thermodynamic proof for the occurrence of this phenomenon is now available. C(H)-region effects on affinity and specificity suggest new mechanisms for generating antibody diversity and… CONTINUE READING

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