The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2.

@article{Seele2015TheIM,
  title={The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2.},
  author={Jana Seele and Lena-Maria Hillermann and Andreas Beineke and Maren Seitz and Ulrich von Pawel-Rammingen and Peter Valentin-Weigand and Christoph Georg Baums},
  journal={Vaccine},
  year={2015},
  volume={33 19},
  pages={2207-2212}
}
Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immunogenicity and protective efficacy of a recombinant vaccine including IdeSsuis. Vaccination with rIdeSsuis elicited antibodies efficiently neutralizing the IgM protease activity… CONTINUE READING
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