The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions.

@article{Harding2010TheIO,
  title={The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions.},
  author={Fiona A Harding and Marcia M Stickler and Jennifer Razo and Robert B Dubridge},
  journal={mAbs},
  year={2010},
  volume={2 3},
  pages={256-65}
}
Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for their targets, convey effector functions and enjoy robust manufacturing procedures. Humanization of murine monoclonal antibodies has vastly improved their in vivo tolerability. Humanization, the replacement of mouse constant regions and V framework regions for human sequences, results in a significantly less immunogenic product. However, some humanized and even fully human sequence-derived antibody… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS