The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

@article{Tynan2005TheIO,
  title={The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation},
  author={Fleur E. Tynan and Diah Elhassen and Anthony W. Purcell and Jacqueline M. Burrows and Natalie A. Borg and John J. Miles and Nicholas Williamson and Kate J. Green and Judy T. Tellam and Lars Kjer-Nielsen and James McCluskey and Jamie Rossjohn and Scott R. Burrows},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={1249 - 1260}
}
Thousands of potentially antigenic peptides are encoded by an infecting pathogen; however, only a small proportion induce measurable CD8(+) T cell responses. To investigate the factors that control peptide immunogenicity, we have examined the cytotoxic T lymphocyte (CTL) response to a previously undefined epitope ((77)APQPAPENAY(86)) from the BZLF1 protein of Epstein-Barr virus (EBV). This peptide binds well to two human histocompatibility leukocyte antigen (HLA) allotypes, HLA-B*3501 and HLA-B… CONTINUE READING