The immunocytochemical localisation of 'substance-P-degrading enzyme' within the rat spinal cord.


The regional distribution of a neural endopeptidase ('substance-P-degrading enzyme', SPDE) within the rat spinal cord, as visualised by immunocytochemistry, closely paralleled the distribution of major substance P-containing nerve fibre systems. Thus, SPDE-immunoreactivity was present in laminae I and II of the dorsal horn, in large diameter neurones of the… (More)


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