The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.

@article{Rotrosen2002TheIT,
  title={The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.},
  author={D. Rotrosen and J. B. Matthews and J. Bluestone},
  journal={The Journal of allergy and clinical immunology},
  year={2002},
  volume={110 1},
  pages={
          17-23
        }
}
  • D. Rotrosen, J. B. Matthews, J. Bluestone
  • Published 2002
  • Medicine
  • The Journal of allergy and clinical immunology
    • Immune tolerance therapies are designed to reprogram immune cells in a highly specific fashion to eliminate pathogenic responses while preserving protective immunity. A concept that has tantalized immunologists for decades, the development of tolerance-inducing therapies, would revolutionize the management of a wide range of chronic and often debilitating diseases by obviating the need for lifelong immunosuppressive regimens. The advances of the past decade have provided a more detailed… CONTINUE READING
    View PDF
    41 Citations
    Highly Influential Citations
    3
    Background Citations
    10
    Methods Citations
    4
    41 Citations
    Citation Type

    Citation Type

    The immunological monitoring of alloreactive responses in liver transplant recipients: A review
    • 28
    Neonatal tolerance to a Th2-mediated autoimmune disease generates CD8+ Tc1 regulatory cells.
    • 13
    Frontiers in nephrology: immune tolerance to allografts in humans.
    • 42
    • PDF
    Transplantation tolerance in pediatric recipients: Lessons and challenges
    • 12
    Tolerance induction in clinical transplantation: the pending questions
    • 30
    New take on comparative immunology: relevance to immunotherapy.
    • 7
    The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity
    • 47
    Overview of Immunity
    • 5
    Treatment of Transplantation Rejection and Multiple Sclerosis
    • 2
    T-Cell Maturation and Activation
    • 7
    • PDF

    References

    SHOWING 1-10 OF 30 REFERENCES
    Transplantation tolerance: mechanisms and strategies?
    • 18
    Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: a review of efficacy and mechanisms.
    • 77
    Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection.
    • 134
    Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
    • 323
    CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
    • A. Kirk, D. Harlan, +7 authors S. Knechtle
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 919
    • PDF
    Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts.
    • 125
    An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome
    • 288
    Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients.
    • 33
    LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response1
    • 279
    • PDF
    Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
    • 212