The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.

@article{Rotrosen2002TheIT,
  title={The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.},
  author={Daniel Rotrosen and Jeffrey B. Matthews and Jeffrey A. Bluestone},
  journal={The Journal of allergy and clinical immunology},
  year={2002},
  volume={110 1},
  pages={
          17-23
        }
}
Immune tolerance therapies are designed to reprogram immune cells in a highly specific fashion to eliminate pathogenic responses while preserving protective immunity. A concept that has tantalized immunologists for decades, the development of tolerance-inducing therapies, would revolutionize the management of a wide range of chronic and often debilitating diseases by obviating the need for lifelong immunosuppressive regimens. The advances of the past decade have provided a more detailed… 

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