The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.

@article{Baron2006TheIS,
  title={The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.},
  author={Fr{\'e}d{\'e}ric Baron and Rainer F Storb},
  journal={Best practice & research. Clinical haematology},
  year={2006},
  volume={19 4},
  pages={
          637-53
        }
}
In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies. After briefly summarizing the development of the theory of cancer immune surveillance, we describe how initial studies discovering the efficacy of the immune-mediated graft-versus-tumor effects after allogeneic hematopoietic cell transplantation led to new transplantation approaches (termed non-myeloablative transplantation… CONTINUE READING

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