The immune system and kidney disease: basic concepts and clinical implications

  title={The immune system and kidney disease: basic concepts and clinical implications},
  author={C. Kurts and U. Panzer and H. Anders and A. Rees},
  journal={Nature Reviews Immunology},
  • C. Kurts, U. Panzer, +1 author A. Rees
  • Published 2013
  • Medicine, Biology
  • Nature Reviews Immunology
  • The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells… CONTINUE READING
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