The immune system and cardiac repair.

  title={The immune system and cardiac repair.},
  author={Nikolaos G Frangogiannis},
  journal={Pharmacological research},
  volume={58 2},
Myocardial infarction is the most common cause of cardiac injury and results in acute loss of a large number of myocardial cells. Because the heart has negligible regenerative capacity, cardiomyocyte death triggers a reparative response that ultimately results in formation of a scar and is associated with dilative remodeling of the ventricle. Cardiac injury activates innate immune mechanisms initiating an inflammatory reaction. Toll-like receptor-mediated pathways, the complement cascade and… CONTINUE READING
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View 14 Excerpts
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Molecular mechanisms of blood vessel growth.

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