The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease.

@article{Brookes1992TheIR,
  title={The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease.},
  author={Suzanne Brookes and Y. A. Pandolfino and Timothy John Frederick Mitchell and Patrick J. W. Venables and Warren Shattles and Duncan A. Clark and Andrew R Entwistle and Ravinder Nath Maini},
  journal={British journal of rheumatology},
  year={1992},
  volume={31 11},
  pages={
          735-42
        }
}
To examine the immune response to retroviral gag sequences in autoimmune disease, we measured antibody levels to synthetic peptides representing the major epitopes on HTLV-1 p19 gag and a homologous sequence on the endogenous retrovirus, HRES-1, in sera from 121 patients with autoimmune disease and 52 healthy controls. In the absence of HTLV-1 antibodies, using a conventional diagnostic assay, significantly elevated levels of antibodies to the HTLV-1 peptide were found in 23% of multiple… CONTINUE READING
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