The immune response of Drosophila melanogaster

  title={The immune response of Drosophila melanogaster},
  author={Vincent Leclerc and Jean Marc Reichhart},
  journal={Immunological Reviews},
Summary:  The response of the fruit fly Drosophila melanogaster to various microorganism infections relies on a multilayered defense. The epithelia constitute a first and efficient barrier. Innate immunity is activated when microorganisms succeed in entering the body cavity of the fly. Invading microorganisms are killed by the combined action of cellular and humoral processes. They are phagocytosed by specialized blood cells, surrounded by toxic melanin, or lysed by antibacterial peptides… 

Recent advances in the innate immunity of invertebrate animals.

The present status of the molecular structures and functions of various defense components that participated in innate immune systems have been established in Arthropoda, such as, insects, the horseshoe crab, freshwater crayfish, and the protochordata ascidian are described.

Drosophila melanogaster embryonic haemocytes: masters of multitasking

Drosophila melanogaster haemocytes constitute the cellular arm of a robust innate immune system in flies: they undergo complex migrations and carry out several non-immune functions that are crucial for successful embryogenesis.

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Immune systems evolution.

The differences and the striking similarities of the immune mechanisms across different taxa in the context of evolution and the selective pressures that favoured the development of the adaptive immune system and the lymphoid organs are discussed.

The growing promise of Toll-deficient Drosophila melanogaster as a model for studying Aspergillus pathogenesis and treatment.

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A drosomycin–GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

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Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes.

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Toll-related receptors and the control of antimicrobial peptide expression in Drosophila.

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The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

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NF-kappaB signaling pathways in mammalian and insect innate immunity.

Recent advances in understanding the signaling pathways in mammalian and Drosophila innate immunity are discussed, with emphasis on the mechanisms by which NFB/Rel family proteins are activated.

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