The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.

@article{GallitanoMendel2007TheIE,
  title={The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.},
  author={Amelia Gallitano-Mendel and Yukitoshi Izumi and Kazuhiro Tokuda and Charles F Zorumski and Maureen P. Howell and Louis J. Muglia and David F. Wozniak and Jeffrey D. Milbrandt},
  journal={Neuroscience},
  year={2007},
  volume={148 3},
  pages={633-43}
}
Stress and exploration of novel environments induce neural expression of immediate early gene transcription factors (IEG-TFs). However, as yet no IEG-TF has been shown to be required for the normal biological or behavioral responses to these stimuli. Here we show that mice deficient for the IEG-TF early growth response gene (Egr) 3, display accentuated behavioral responses to the mild stress of handling paralleled by increased release of the stress hormone corticosterone. Egr3-/- mice also… CONTINUE READING

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Because stress and novelty stimulate hippocampal long - term depression ( LTD ) , and because abnormalities in habituation to novelty and Y - maze performance have been associated with LTD deficits , we examined this form of synaptic plasticity in Egr3-/- mice .
Because stress and novelty stimulate hippocampal long - term depression ( LTD ) , and because abnormalities in habituation to novelty and Y - maze performance have been associated with LTD deficits , we examined this form of synaptic plasticity in Egr3-/- mice .
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